BRIDGING THE GAP BETWEEN SCIENCE AND PATIENTS

2 to 4 novel antibiotics by 2030

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The growing threat of AMR

The world is losing its most powerful tool in healthcare: antibiotics.

The reason: rapidly rising antibiotic-resistant infections – also called antimicrobial resistance, or AMR.

These infections can affect anyone, of any age, in any country. AMR is a universal issue that impacts us all – we are all at risk.

Antibiotic resistance undermines every aspect of medicine today. We rely on the availability of effective antibiotics to be able to do everything from wisdom tooth extractions to organ transplantation to cancer chemotherapy.

The fragile antibiotic pipeline is close to collapse

Despite the huge societal costs of AMR, there is no viable market for new antibiotics and therefore little funding available to support clinical research.

As a result, important antibiotics in the early stages of development may never get over the “valley of death” to reach patients.

Bridging the gap

$1

The ground-breaking AMR Action Fund expects to invest more than US$1 billion to bridge the funding gap and respond to the AMR threat.

2-4

The Fund aims to bring 2-4 new antibiotics to market this decade that will save patient lives.

The concept of the AMR Action Fund has been developed in collaboration with the World Health Organization, the European Investment Bank, and the Wellcome Trust. It aims to overcome key technical and funding barriers of late-stage antibiotic development and will work with governments to ensure there is a sustainable pipeline of new antibiotics to fight superbugs.

Together, we must act now to safeguard our future from this global threat.

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AMR is a slow tsunami that threatens to undo a century of medical progress. I very much welcome this new engagement of the private sector in the development of urgently-needed antibacterial treatments. WHO looks forward to working with the AMR Action Fund to accelerate research to address this public health crisis.
— Dr Tedros Adhanom Ghebreyesus
Director General World Health Organization
EIB is actively supporting identified market failures with innovative financial instruments, antimicrobial resistance is clearly one. We welcome the opportunity to join forces with public and private actors, such as the pharmaceutical industry, philanthropic funders, multilateral development banks, and the World Health Organization to tackle this threat. The initiative is aligned with the EIB’s core objectives in health and we are proud to be part of the origination group of the new AMR Action Fund.
— Werner Hoyer
President, European Investment Bank
My 18-month-old son Simon woke up one morning screaming in agony. Within 24 hours, he died from a drug-resistant infection that doctors were powerless to stop. Had effective antibiotics been available, he would still be with us today. For the first time in years, there is real hope on the horizon. The fund’s investment in new antibiotics will provide funding for the sorts of lifesaving treatments that could have saved my son.
— Everly Macario
Public Health Advocate

An Industry-led Fund

The pharmaceutical industry, in collaboration with the WHO, EIB, and the Wellcome Trust, came together to design the AMR Action Fund. So far, over 20 leading pharmaceutical companies have pledged to invest nearly US$1 billion through the new AMR Action Fund.

The AMR Action Fund will bridge innovative candidates in the pipeline through the most challenging later stages of drug development, ultimately providing governments time to make the necessary policy reforms to enable a sustainable antibiotic pipeline.

The AMR Action Fund expects to invest more than US$1 billion with the support of future partners, such as philanthropies, development banks and multilateral organizations. It will form one of the largest collective ventures ever set up to address AMR.

Check out this new article in @WHOBulletin on the @AMRActionFund, a true collaboration between the private sector (@IFPMA @ThomasCueni), philanthropies (@Wellcome_AMR @Jeremy_Knox ), development banks (@EIB), and multilaterals (@WHO @PeterBeyer3) https://t.co/17HtyGgzMb

- December 3, 2020

@UKAMREnvoy: Thank you to @DKAMBinKorea, @Heunicke, and Minister Park Neung-hoo for hosting today's webinar on how we can turn our evidence into action on AMR 🇩🇰🇰🇷🇬🇧

Working together across the world, we can keep everyone safe @ICARS_global @IVIHeadquarters 🌍💊

- December 3, 2020

@ClancyNeil: We wrote about just this thing in Open Forum Infect Dis. #AMRActionFund is welcome initiative supporting new antibiotic development & battling #AMR, but not a solution in itself. #IDtwitter can get engaged through @IDSAInfo or other avenues. https://t.co/RF9caDqbg1 https://t.co/UD8hehtfWK

- December 3, 2020

Fantastic panel at #WHS2020 - unlike COVID-19, AMR is a predictable and preventable threat. Let's take action now to prepare! https://t.co/cXbCjnRqx1

- December 3, 2020

Great question! We will focus on clinical development (mostly post-Phase 1) - this is the major gap in funding for R&D https://t.co/4HrgrkyTds

- December 3, 2020

Great question! The Fund's investments will focus on assets that address pathogens that have been prioritized by @WHO and @CDCgov - we are focused on maximizing public health impact with our resources! https://t.co/PbPkjTrKMv

- December 3, 2020